Publications and Presentations

This page includes scientific papers published as a result of this project, conference presentations about the project and general Information on the project, e.g. project presentation, brochures, posters and relevant papers by partners.

Scientific Papers

"Diagnosis and management of hypotension in neonates".
Ryan Farrugia, Hector Rojas, Heike Rabe. Future Cardiology, September 2013, Vol. 9, No. 5, Pages 669-679 , DOI 10.2217/fca.13.59.

"Dobutamine in Paediatric Population: A Systematic Review in Juvenile Animal Models".
Victoria Mielgo, Adolf Valls i Soler, Carmen Rey-Santano. PLoS ONE 9(4): e95644. doi:10.1371/journal.pone.0095644 Open Access

"Successful private/public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines".
L.Ruggieri, V.Giannuzzi, P.Baiardi, F.Bonifazi, E.H.Davies, C.Giaquinto, D.Bonifazi, M.Felisi, C.Chiron, R.Pressler, H.Rabe, M.J.Whitaker, A.Neubert, E.Jacqz-Aigrain, I.Eichler, M.A.Turner, A.Ceci. Eur J Pediatr (2015) 174: 481. doi:10.1007/s00431-014-2398-z. Open Access

"Short-term outcome of very-low-birthweight infants with arterial hypotension in the first 24h of life".
Kirstin Faust, Christoph Härtel, Michael Preuß, Heike Rabe, Claudia Roll, Michael Emeis, Christian Wieg, Miklos Szabo, Egbert Herting, Wolfgang Göpel for the Neocirculation project and the German Neonatal Network (GNN). Archives of Disease in Childhood - Fetal and Neonatal Edition 2015;100:F388-F392. doi:10.1136/archdischild-2014-306483.

"A Literature Review of the Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates".
Mahoney L, Shah G, Crook D, Rojas-Anaya H, Rabe H. Pediatr Cardiol (2016) 37: 14. doi:10.1007/s00246-015-1263-9 .

"Hemodynamic and metabolic effects of a new pediatric dobutamine formulation in hypoxic newborn pigs".
Victoria E. Mielgo, Adolf Valls-i-Soler, Juan M. Lopez-de-Heredia, Heike Rabe and Carmen Rey-Santano ; on behalf of NEO-CIRC Consortium. Pediatric Research (2017) 81, 511–518. doi: 10.1038/pr.2016.257.

"Quantitative determination of dobutamine in newborn pig plasma samples by HPLC–MS/MS".
O.E.Albóniga, M.L.Alonso, M.E.Blanco, O.González, A.Grisaleña, M.A.Campanero, R.M.Alonso. Journal of Pharmaceutical and Biomedical Analysis 145 (2017) 178–185. doi: 10.1016/j.jpba.2017.06.050

"Inotropes for preterm babies during the transition period after birth: friend or foe?".
Rabe H, Rojas-Anaya H. Arch Dis Child Fetal Neonatal Ed. 2017; 102(6): F547-F550. doi: 10.1136/archdischild-2016-311709

"Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data".
Ergenekon E, Rojas-Anaya H, Bravo MC, Kotidis C, Mahoney L, Rabe H. Current Pharmaceutical Design. Volume 23. E-pub ahead of print. . doi: 10.2174/1381612823666170918122755.

"Understanding the Stability of Dopamine and Dobutamine Over 24 h in Simulated Neonatal Ward Conditions".
Kirupakaran K, Mahoney L, Rabe H, Patel BA. Pediatr Drugs (2017) 19: 487. doi: 10.1007/s40272-017-0234-4.

Intra- and Inter-rater Agreement of Superior Vena Cava Flow and Right Ventricular Outflow Measurements in Late Preterm and Term Neonates.
Mahoney L, Fernandez-Alvarez JR, Rojas-Anaya H, Aiton N, Wertheim D, Seddon P, Rabe H. (2018). J Ultrasound Med. 2018 Feb 24. Epub ahead of print. doi: 10.1002/jum.14568.

Conference Presentations

A systematic review of Pharmacokinetics (PK) of Dobutamine for use in neonates and children.
Oral presentation at the 4th Congress of the European Academy of Paediatric Societies (EAPS). 08/10/2012, Istanbul, Turkey

Cardiovascular Maladaptation in VLBW infants (inc. NEO-CIRC project).
Oral presentation by H Rabe (BSUH) on 22/11/2012, Bilbao, Spain.

New methods for the future. Circulation workshop: Measurement of tissue oxygenation and microcirculation.
Oral presentation at the Society of Neonatology and Paediatric Intensive Care, 39th Annual Conference, Freiburg, Germany.

Arterielle Hypotension bei sehr kleinen Frühgeborenen am ersten Lebenstag.
Oral presentation at the Society of Neonatology and Paediatric Intensive Care, 39th Annual Conference, Freiburg, Germany.

The right medicine for neonates.
Oral presentation at BSMS Research Day. 04/09/2013, Falmer, UK.

Dobutamine, what is it good for?
Oral presentation at the European Society for Paediatric Research, 54th Annual Meeting. 14/10/2013, Porto, Portugal.

NEOCIRC: Success Story.
Oral presentation at the Horizon 2020 conference held in Gazi University. 15/11/2013, Ancara, Turkey.

Neonatal Circulation.
Oral presentation at the Regional Neonatal Nurse Development days. 30/05/2014 & 23/10/2014, Brighton, UK.

Neo-Circulation.
Oral presentation at the Wessex-Oxford Neonatal Study Day. 31/07/2014, Southampton, UK.

Hemodynamic And Metabolic Effects Of A New Pediatric Dobutamine Formulation In Hypoxic Newborn Piglets.
Poster at the 5th Congress of the European Academy of Paediatric Societies EAPS. 19/10/2014, Barcelona, Spain.

First Annual Neonatal Scientific Workshop: Roadmap for Applying regulatory Science to Neonates - Clinical Outcome Assessments.
Oral presentation at the Critical Path Institute, FDA, Burroughs Wellcome Fund. 29/10/2014, FDA White Oak Campus, Silver Spring, Maryland, USA.

Hemodynamic And Metabolic Effects Of A New Pediatric Dobutamine Formulation In Hypoxic Newborn Piglets.
Selected Abstracts of the 5th Congress of the European Academy of Paediatric Societies EAPS. Barcelona, Spain. Arch Dis Child 2014; 10/2014; 99 (Suppl 2): A146.

A Study To Validate The Duration Of Assessment Of Baseline NIRS Values In Preterm Babies With Echocardiographically Confirmed PDA.
Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015. J Pediatr Neonat Individual Med. 2015;4(2).

Haemodynamics In Preterm Infants With Patent Ductus Arteriosus (HAPI-PDA Study): A Pilot Study.
Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015. J Pediatr Neonat Individual Med. 2015;4(2).

Point of care functional echocardiographic inter- and intra-observer variability: right ventricular outflow & superior vena cava flow in well and unwell newborn infants.
Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015. J Pediatr Neonat Individual Med. 2015;4(2).

Novel non-invasive measurements in the assessment of normal cardio- vascular adaptation in term & near term infants.
Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20, 2015. J Pediatr Neonat Individual Med. 2015;4(2).

The NeoAdapt Project: Novel non-invasive measurements in the assessment & treatment of cardiovascular compromise in severely unwell term & near term infants.
ePoster. 1st Congress of joint European Neonatal Societies (jENS 2015); Budapest (Hungary); September 16-20th 2015. J Pediatr Neonat Individual Med. 2015;4(2).

The NeoAdapt Project: Novel non-invasive measurements in the assessment & treatment of cardiovascular compromise in severely unwell term & near term infants.
NeoCard 2015: 6th Neonatal Cardiology & Haemodynamics Conference, Middleborough, UK October 12-14th 2015.

Haemodynamically Significant Patent Ductus Arteriosus Impairs Cerebral Oxygenation and May Be Linked With Intraventricular Haemorrhage.
Neonatal Society Autumn Meeting, London, UK 5th November 2015.

Non-Invasive Measurements In The Assessment Of Normal Cardiovascular Adaptation In Term & Near Term Infants.
Neonatal Society Autumn Meeting, London, UK 5th November 2015.

Non-Invasive Assessment of Normal Cardiovascular Adaptation in Term & Near Term Infants.
Pediatric Academic Societies Meeting. Baltimore. USA. April 30th- May 3rd 2016. EPAS:3859.541.

NEO-CIRC-003.
Pellicer A. Oral Presentation at European Neonatal Brain Club (ENBC), Santorini, Greece, September 2016.

Late Preterm Infants: Distinctly Different Cardiovascular Adaptation To Term Neonates.
Mahoney L, Wertheim D, Fernandez Alvarez J.R, Aiton N, Rojas-Anaya H, Seddon P, Rabe H. Oral presentation at at EAPS 2016, Geneva, Switzerland, 22-25 October 2016. Eur. J. Pediatr. 2016; 175 (11): 1468. doi:10.1007/s00431-016-2785-8.

Non- Invasive Measurement Of Haemodynamics In Late Preterm Infants Requiring Intensive Care.
Mahoney L, Wertheim D, Fernandez Alvarez J.R, Aiton N, Rojas-Anaya H, Seddon P, Rabe H. Oral presentation at EAPS 2016, Geneva, Switzerland, 22-25 October 2016. Eur. J. Pediatr. 2016; 175 (11): 1556. doi:10.1007/s00431-016-2785-8.

A 24 Hour Study On The Stability Of Dopamine And Dobutamine Under Laboratory Simulated Neonatal Ward Conditions.
Kirupakaran K, Mahoney L, Patel B, Rabe H. Oral presentation at EAPS 2016, Geneva, Switzerland, 22-25 October 2016. Eur. J. Pediatr. 2016; 175 (11): 1566-1567. doi:10.1007/s00431-016-2785-8.

Validation Of PDA Severity Score In Predicting Chronic Lung Disease (CLD) In Extremely Preterm Infants With Patent Ductus Arteriosus.
Kotidis, C., Weindling, M., Subhedar, N., & Turner, M. Oral presentation at EAPS 2016, Geneva, Switzerland, 22-25 October 2016. Eur. J. Pediatr. 2016;175 (11): 1557-1558. doi:10.1007/s00431-016-2785-8.

Neonatal Haemodynamics: An Empirical Evaluation Of One Causal Pathway.
Kotidis, C., Weindling, M., & Turner, M. Poster presentation at EAPS 2016, Geneva, Switzerland, 21st - 25th October 2016. Eur. J. Pediatr. 2016; 175 (11): 1702. doi:10.1007/s00431-016-2785-8.

Non-Infective Influences On A Continuous Predictor Of Infection (HeRO Score).
Lucas, C., Rodgers, B., Patel, A., Turner, M., Weindling, M., & Kotidis, C. Poster presentation at EAPS 2016, Geneva, Switzerland, 21st - 25th October 2016. Eur. J. Pediatr. 2016; 175 (11): 1775-1776. doi:10.1007/s00431-016-2785-8

Correlation of vital parameters and superior vena cava (SVC) flow assessment in preterm infants ≤32 weeks of gestation.
G. Zaharie, M. Matyas, L. Blaga, T. Drugan, V. Obada, M. Hasmasanu, O. Behalf of the NEO-CIRC Consortium. Poster presentation at EAPS 2016, Geneva, Switzerland. 21st - 25th October 2016. Eur. J. Pediatr. 2016; 175 (11): 1712. doi:10.1007/s00431-016-2785-8

Comparison of Cardiovascular Adaptation in Infants Requiring Intensive Care or Total Body Cooling.
Mahoney L, Wertheim D, Fernandez Alvarez J.R, Aiton N, Rojas-Anaya H, Seddon P, Rabe H. Poster presentation at EAPS 2016. Eur. J. Pediatr. 2016; 175 (11): 1582-1583. doi:10.1007/s00431-016-2785-8.

Biomarkers associated with haemodynamically significant patent ductus arteriosus.
Kotidis C, Weindling AM, Turner M. Oral presentation at Neonatal Society 2016 Autumn Meeting, London, UK, 10th November 2016.

Cardiovascular Support in the Preterm Infant with Circulatory Impairment.
Pellicer A. Oral Presentation at 6th International Congress of Union of European and Perinatal Societies (UENPS). Valencia, Spain, 23-25 November 2016.

Neonatal cardiovascular and cerebral function after antenatal maternal exposure to magnesium sulfate.
Kotidis, C., Sharp, A., Alfirevic, Z., Weindling, M., & Turner, M. Oral presentation at Developmental Perinatal and Paediatric Pharmacology Congress, Leuven, Belgium, 20th - 23rd June 2017.

Phase Difference, a Novel Tool for the Assessment of PDA and Haemodynamics in Extremely Preterm Neonates.
Kotidis, C, Wertheim D, Weindling M, Rabe H, Turner M. Oral presentation at Neonatal Society Summer Meeting, Brighton, UK, 29th - 30th June 2017.

Cerebral Biomarkers in Extremely Preterm Infants With a Patent Ductus Arteriosus.
Kotidis, C.,Turner, M., & Weindling, A. M. Oral presentation at XXV Biennial Meeting of the International Perinatal Collegium, Edinburgh, UK, 2nd - 6th July 2017. Acta Paediatr, 2017; 106:30. doi:10.1111/apa.13877

Low blood pressure during the first 24 hours – does it matter?
Faust K, Härtel C, Rabe H, Roll C, Wieg C, Wilke M, Szabo M, Herting E, Goepel W. Poster presentation at the “Recent Advances in Neonatology” meeting 2017, Würzburg, Germany, 08-10 October 2017. Won 3rd Poster Prize.

Prognostic value of the value of SVC flow in the first day at the prematures ≤32 weeks of gestation.
Zaharie GC, Drugan T, Muresan D, Matyas M, Rabe H, Hasmasanu M. Poster presentation at 2nd Congress of joint European Neonatal Societies jENS 2017, Venice, Italy, 31 October - 04 November 2017.

Patent ductus arteriosus, cerebral haemodynamics and intraventricular haemorrhage in preterm neonates: a causal pathway study
C. Kotidis; M. Weindling; A. Eleuteri; H. Rabe; M. Turner. Oral presentation at 2nd Congress of joint European Neonatal Societies jENS 2017, Venice, Italy, 31 October - 04 November 2017.

Experiences from the NEO-CIRC trial
Heike Rabe. Oral presentation at 2nd Congress of joint European Neonatal Societies jENS 2017, Venice, Italy, 31 October - 04 November 2017.

General Information

MHH Info- Forschen und Wissen- EU fördert weitere MHH-Projekte:
The NEOCIRC project in the November 2011 edition of the MHH monthly magazine distributed to members of the university, students, patients and press .

European Commission's press release:
The NEOCIRC project in the Research and Innovation publication of April 2012

European Society for Paediatric Research:
The NEOCIRC project in the Newsletter of November 2012

EU funding for research and innovation 2014-2020: Seizing the opportunities for NHS organisations
NEOCIRC was included as a case study in the December 2013 briefing from the NHS European Office. Audience is all organisations that commission and provide NHS services in the UK

1st Period Progress Report - Summary
The NEOCIRC project summary report for months from October 2011 to March 2013

2nd Period Progress Report - Summary
The NEOCIRC project summary report for months from April 2013 to September 2014

3rd Period Progress Report - Summary
The NEOCIRC project summary report for months from October 2014 to March 2016

4th Period Progress Report - Summary
The NEOCIRC project summary report for months from April 2016 to September 2017